Definitely! In modern AU, she gets diagnosed with autism which makes her all the more isolated because its the nature of the treatment people with autism receive. But in canon despite the lack of diagnoses and understanding of autism, Nokota is treated as an outcast, a lost cause, borderline "hysteric". But Ryder really nails in it, even just knowing her behaivor is uncouth in her village he feels the need to protect her more by hovering over any independence she may yearn for. Hes incredibly protective all around.
It really worsens Nokota, she is particularly social so not having that makes her really depressed at times. Even when she escapes in brief moments, she imagines to make friends with everyone and usually it results in...tragedy. I believe even if she met others and was closer to people, it would still be the same as she longed for more freedom.